Manchester United welcome Arsenal to the Emirates as Unai Emery and Jose Mourinho face off for the first time since 2013.
Arsenal go into the game in top form having stretched their unbeaten run to 18 games with victory against Tottenham.
United continue to be short of defensive options, and will hope Chris Smalling and Eric Bailly recover from respective foot and back problems.
The Red Devils are already 16 points behnid title favourites Manchester City. Meanwhile, Arsenal are in hot form and are unbeaten since August. The 4-2 derby win over Tottenham has propelled Unai Emery’s side into the top four.
Arsenal’s Granit Xhaka is suspended after accumulating five yellow cards. And Mesut Ozil, who missed out against Spurs, is unlikely to feature due to back spasms.
They need the three points if they are going to have any chance of making the top four by the end of the year, which is Jose Mourinho’s target.